GEL lab researchers Oliver Pain and Professor Angelica Ronald have published new research showing that there is a genetic link between specific adolescent psychotic-like experiences in the community and schizophrenia. Genetic links were also identified between negative symptoms (including self-reported anhedonia, and parent-reported symptoms including lack of motivation and associality) and schizophrenia, and between negative symptoms and major depressive disorder. The results were obtained through use of a range of statistical genetic methods, applied to data from three European community samples (combined sample N=6,297–10,098).
The paper is published in the American Journal of Medical Genetics, and can be accessed here.
Refrerence: Pain, O., Dudbridge, F., Cardno, A. G., Freeman, D., Lu, Y., Lundstrom, S., Lichtenstein, P., & Ronald, A. (2018). Genome‐wide analysis of adolescent psychotic‐like experiences shows genetic overlap with psychiatric disorders. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics.